\begin{table}
\centering
\begin{tblr}[         %% tabularray outer open
]                     %% tabularray outer close
{                     %% tabularray inner open
colspec={Q[]Q[]Q[]Q[]Q[]},
hline{2}={1-5}{solid, black, 0.05em},
hline{1}={1-5}{solid, black, 0.1em},
hline{6}={1-5}{solid, black, 0.1em},
cell{3-4}{1}={}{font=\itshape, fg=cFFA500, bg=c00FF00},
cell{3-4}{3}={}{font=\itshape, fg=cFFA500, bg=c00FF00},
cell{3-4}{4}={}{font=\itshape, fg=cFFA500, bg=c00FF00},
}                     %% tabularray inner close
\tinytableDefineColor{c00FF00}{HTML}{00FF00}
\tinytableDefineColor{cFFA500}{HTML}{FFA500}
mpg & cyl & disp & hp & drat \\
21.0 & 6 & 160 & 110 & 3.90 \\
21.0 & 6 & 160 & 110 & 3.90 \\
22.8 & 4 & 108 & 93 & 3.85 \\
21.4 & 6 & 258 & 110 & 3.08 \\
\end{tblr}
\end{table} 
