Clinical Trial Simulator

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Documentation for package ‘TrialSimulator’ version 1.3.0

• DESCRIPTION file.
• User guides, package vignettes and other documentation.
• Package NEWS.

Help Pages

arm	Define an Arm
Arms	Class of Arm
calendarTime	Triggering Condition by Calendar Time
controller	Define a Controller
Controllers	Class of Controller
CorrelatedPfsAndOs3	Generate Correlated PFS and OS
CorrelatedPfsAndOs4	Generate Correlated PFS, OS and Objective Response
doNothing	An Action Function that Does Nothing
DynamicRNGFunction	A wrapper of random number generator.
endpoint	Define Endpoints
Endpoints	Class of Endpoint
enrollment	Triggering Condition by Number of Randomized Patients
eventNumber	Triggering Condition by Number of Events or Non-missing Observations of an Endpoint
fitCoxph	Fit Cox Proportional Hazard Ratio model
fitFarringtonManning	Farrington-Manning test for rate difference
fitLinear	Fit linear regression model
fitLogistic	Fit logistic regression model
fitLogrank	Carry out log rank test
getAdaptiveDesignOutput	Get simulation output in the vignette adaptiveDesign.Rmd
getFixedDesignOutput	Get simulation output in the vignette fixedDesign.Rmd
GraphicalTesting	Class of GraphicalTesting
GroupSequentialTest	Class of GroupSequentialTest
listener	Define a Listener
Listeners	Class of Listener
milestone	Define a Milestone
Milestones	Class of Milestones
PiecewiseConstantExponentialRNG	Generate Time-to-Event Endpoint from Piecewise Constant Exponential Distribution
plot.milestone_time_summary	Plot Triggering Time of Milestones in Simulated Trials
plot.three_state_model	Plot result of three-state ill-death model
rconst	Generate Constant Variable
solveMixtureExponentialDistribution	Solve Parameters in a Mixture Exponential Distribution
solveThreeStateModel	Solve Parameters in a Three-State Ill-Death Model
StaggeredRecruiter	Generate Enrollment Time from Piecewise Constant Uniform Distribution
summarizeDataFrame	Summarize A Data Frame
summarizeMilestoneTime	Summary of Milestone Time from Simulated Trials
trial	Define a Trial
Trials	Class of Trial
weibullDropout	Calculate Parameters of Weibull Distribution as a Dropout Method